COMPOUNDS FOR BIOLOGICAL SCREENING
AND LEAD OPTIMIZATION

We offer special molecular sets, created using complex computational optimization, which allows to maximize diversity and exclude potentionally problematic molecules. They are specifically developed to provide efficient start to research project or to expand a current one.

Targeted Libraries: 

In order to assist researchers with expanding their projects or  jump-starting a new one, we offer special targeted molecular libraries,
which are calculated using complex in-house algorithms. These libraries are  designed based on similarities with existing compounds that have known   activity towards specific targets. Our targeted libraries are designed in a   way that maximizes structural diversity and excludes problematic compounds.   All compounds in targeted libraries have no more than 30 analogues for each 
reference compound with Tamimoto coefficient >0.9. All compounds follow  Rule-of-Five. We offer special libraries for various subsets of targets:  



 Proteases (PROTEASEMARK2 - 8991 compounds)
 Kinases (KINASEMARK2 - 1764 compounds)
 Ligases (LIGASEMARK - 7261 compounds)
 Ion Channels (IONMARK2 - 2597 compounds)
 Coronaviral proteins (COVMARK - 10027 compounds)
 Helicases (HELMARK - 6579 compounds)
 Cancer-related proteins (CANCERMARK - 26190 compounds)
 HIV-related proteins (HIVMARK - 6193 compounds)
 Phosphatases (PHOSMARK - 3191 compounds).

 
 We also offer our legacy targeted libraries for Kinases and Proteases   (KINASEMARK and PROTEASEMARK).

And we also offer a specialized CNS-focused library of small molecular compounds, It includes 4247 compounds, optimized based on high predicted BBB permeability and bioavailability.


 
 

 Diversity Libraries:

Library “Broadway” provides you with full-scale selection of 32600 compounds, representing broad diversity of our whole 1,400,000 molecule stock. This is a library of choice if you want to cover wider range of possible interactions or looking to expand your compound selection.

Library “Avenue” is optimized for smaller scale assays. It consists of highly diverse selection of 3400 small molecules, with emphasis on keeping database size manageable without losing structural variety. This selection is the perfect way to boost your research Project.

We can also provide access to a special subset of our diversity library, filtered to minimize potential toxicity upon your request.

 

You can download special databases as well as our other products on this here. Libraries are available as 96 and 384-wells plate sets, as dry powder or frozen DMSO solutions, or on a dry film. We can provide collections in other formats, including your own, if requested. Partial purchase option is available.

We will also be happy to replenish molecules, should you require them later as well as supply you compounds with related structural properties.

If you have any specific needs for your project, we can provide adjusted compound library based on your request. Feel free to download the brochureFor any further questions and additional information,  please  contact our sales office:   This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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